| Jim Henson | Kermit the Frog/Rowlf/Dr. Teeth/Waldorf/Swedish Chef/Ernie/Newsman/Horse carriage driver (uncredited) |
| Frank Oz | Miss Piggy/Fozzie/Animal/Sam the Eagle/Swedish Chef (hands)/Bert (uncredited)/Cookie Monster (uncredited)/Ocean Breeze Soap board member (uncredited) |
| Juliana Donald | Jenny |
| Dabney Coleman | Martin Price |
| Dave Goelz | The Great Gonzo/Zoot the Sax Player/Chester Rat/Bill the Frog/Penguin/Dr. Bunsen Honeydew/Beauregard/Fozzie Bear (assistant) (uncredited) |
| Steve Whitmire | Rizzo the Rat/Gill the Frog/Baby Kermit/Dog/College student in audience (uncredited) |
| Lonny Price | Ronnie Crawford |
| Art Carney | Bernard Crawford |
| Gregory Hines | Roller skater |
| Joan Rivers | Perfume saleswoman |
| Liza Minnelli | Herself |
| Frances Bergen | Leonard Winesop's receptionist |
| John Landis | Leonard Winesop |
| Kathryn Mullen | Jill the Frog |
| Brian Muehl | Tatooey the Rat/Beth Bear/Bear |
| James J. Kroupa | Additional Muppet Performer |
| Melissa Whitmire | Additional Muppet performer |
| Glenngo King | Additional Muppet performer |
| Cheryl Bartholow | Additional Muppet performer |
| Mary Lou Harris | College student |
| Joanne Hamlin | Woman in Price's office |
| Norman Bush | Second cop |
| Alice Spivak | Customer in Pete's |
| Dorothy Baxter | Elevator passenger |
| Susan Miller-Kovens | Elevator passenger |
| Sinead Maguire | Elevator passenger |
| Ron Foster | Man in Winesop's office |
| Vic Polizos | Construction worker |
| Chet Washington | Construction worker |
| James Bryson | Customer in Pete's |
| Viola Borden | Bingo caller |
| Maree Dow | Woman in the bleachers |
| Michael Connolly | Maitre d' at Sardi's |
| Ruth Button | Customer at Sardi's |
| Richard Dubois | Customer at Sardi's |
| Jane Hunt | Customer at Sardi's |
| Harriet Rawlings | Customer at Sardi's |
| Gary Tacon | Thief in Central Park |
| Mark Marrone | Chauffeur |
| Peter Baird | Additional Muppet performer |
| Fran Brill | Additional Muppet performer/News reporter |
| Charles Francis Corbett | Additional Muppet performer |
| Brian Henson | Additional Muppet performer |
| Rollin Krewson | Additional Muppet performer |
| Joel Leder | Additional Muppet performer |
| Jim Martin | Additional Muppet performer |
| Todd Stockman | Additional Muppet performer |
| Gabriel Velez | Additional Muppet performer |
| Jerry Nelson | Camilla/Lew Zealand/Floyd/Crazy Harry/Pops (uncredited)/Dog (uncredited) |
| Richard Hunt | Scooter/Janice/Statler/Beaker/Dog (uncredited) |
| Louis Zorich | Pete |
| James Coco | Mr. Skeffington |
| Linda Lavin | Kermit's doctor |
| Elliott Gould | Cop in Pete's |
| Brooke Shields | Customer in Pete's |
| Edward I. Koch | Himself |
| Vincent Sardi | Himself |
| Karen Prell | Yolanda Rat |
| Bruce Edward Hall | Masterson the Rat/Beth Bear |
| David Rudman | Additional Muppet performer |
| Michael Earl | Additional Muppet performer |
| Timothy De Haas | Additional Muppet performer |
| Steve Burnett | College student |
| Gates McFadden | Mr. Price's secretary |
| Hector Troy | First cop |
| Nancy Kirsch | Screaming woman |
| John Bentley | Train conductor |
| Stephen Sherrard Hicks | Elevator passenger |
| John Maguire | Elevator passenger |
| Trisha Noel | Elevator passenger |
| Michael Hirsch | Man in Winesop's office |
| Kenneth MacGregor | Construction worker |
| Graham Brown | Mr. Wrightson |
| Chico Kasindir | Customer in Pete's |
| Paul Stolarsky | Aquacade announcer |
| Don Quigley | Man in the bleachers |
| Wade Barnes | Customer at Sardi's |
| Lee-Ann Carr | Customer at Sardi's |
| Diana Hayes | Customer at Sardi's |
| Jaqueline Page | Sardi's customer |
| Milton Seaman | Customer at Sardi's |
| Joe Jamrog | Cop in Central Park |
| Cyril Jenkins | The Minister |
| Robert Armin | Additional Muppet performer |
| Cheryl Blaylock | Additional Muppet performer |
| Edward G. Christie | Additional Muppet performer |
| Faz Fazakas | Additional Muppet performer |
| Heather Henson | Girl serving drinks at beer hall |
| David Lazer | Customer at Sardi's |
| Ronn Lucas | Additional Muppet performer |
| Martin P. Robinson | Bear/Additional Muppet performer/College student in audience |
| Tom Van Dell | Theater Patron |
| Caroly Wilcox | Additional Muppet performer |
